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The #1 Rated Steroid-free Itch Cream

Developed by dermatologists to stop itch at the source, guaranteed.

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five-stars 4.9 / 5 Stars
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“My doctor gave me samples and my itching was gone within minutes. This is THE miracle cure.”

- Taylor A.

A new standard for itch relief

Dermeleve® is a proprietary topical formulation developed by dermatologists to stop itch at the source. Its SrX-38™ steroid-free formula with skin-healing ingredients has been clinically shown to absorb rapidly into the skin and significantly reduce the sensation of itch.

Apply Dermeleve® to affected areas as needed or as directed by a physician.

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The science behind Dermeleve®

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    The itch cycle

    When itching is triggered either by external stimuli or internal conditions, it triggers an urge to scratch, which in turn results in inflammatory response and skin damage.

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    The solution

    Dermeleve® was specifically developed by dermatologists to target and reduce the sensation of itch, interrupting this vicious cycle and allowing skin to heal.

Skin healing ingredients

  • SrX-38™

    Made with strontium mineral salt, clinically proven to suppress sensory irritation and histamine-induced itch.

  • Ceramides

    Lipid-rich molecules that retain moisture and promote skin regeneration.

  • Hyaluronic acid

    Hyaluronic acid Increases skin hydration up to 96% and helps heal skin more quickly.

  • Vitamins C & E

    Antioxidants that help repair and protect skin from damage.

  • Shea Butter

    Smoothes dry skin while reducing swelling associated with skin conditions.

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Hear from Dr. Dasilva

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Dermeleve has been a game changer for me in many different itching disorders."

Dr. Dasilva, Board Certified Dermatologist

100% satisfaction guarantee

We stand by all of our products with a 100% satisfaction guarantee. So give Dermeleve® a try risk-free! If you are unhappy with your purchase for any reason, we will issue a full refund within 30 days of purchase. No questions asked.

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The proof is in the experience

Hear what patients and doctors have to say about Dermeleve®

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    “I’ve struggled with skin conditions ever since I was a child. Dermeleve is the ONLY product I have used that calms my itching and shortens the length of my flare-ups. It has been literally life-changing”

    - Andy P.

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    “My daughter has been suffering with eczema for years. Products prescribed or over the counter were like putting a bandaid on the problem, until we discovered Dermeleve. My daughter experienced immediate relief & after a few weeks noticed her discoloration/ hyper pigmentation was lightening & her need for scratching had subsided.”

    - Laura W.

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    “I have had this itchy psoriasis on my hands for years! I have tried everything, including steroid ointments, (that I don’t want to use). I tried Dermeleve and immediately the itching was gone.”

    - Shannon R.

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    “As a pharmacist and psoriasis sufferer, I have searched for years for a product that could alleviate my itch as well as improve the appearance of scaly areas. I have tried numerous over the counter and prescription products and none have provided the results I have been searching for. I decided to try Dermeleve and I found complete relief from the annoying itch after just one day. After several applications the scaly, dry areas began to fade and are were well on their way to healing.”

    - Dr Chase V

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    “I had two patients this afternoon, both 60 year old women with airborne contact dermatitis. Both had severe itching for several weeks and both improved 90% within three minutes of the application of Dermeleve anti itch cream. I really love that stuff.”

    - Dr. Evan C, Dermatologist

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    “In the last almost 40 years, this is the first product that has actually worked. It has completely relieved my itching and burning and has been the best product I have ever used.”

    - Seth C., M.D.

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    "I have had chronic hives since I was a baby and other severe skin issues. My dermatologist recommended this cream to me. I’ve used it for almost a week. It works within minutes and lasts upwards of 10 hours. I sleep through the night. No more raw open hives or wounds from scratching the other itchy issues. I am officially giving a 10 ⭐ review and am now a FOREVER Customer. LOVE. LOVE. LOVE.”

    - Drina J

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    “I must once again sing the praises of DERMELEVE Anti-Itch cream. In both of my itching scabies patients I applied some DERMELEVE in the office and within a minute they were itch-free.”

    - Dr Adam C, Dermatologist

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    “I have suffered from skin allergies for a very long time. OTC products as well as prescribed cortisone don’t compare with the effect of this product. Run, don’t walk if you need something like this.”

    - Erin F.

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    “I just had a brachioradial pruritus walk in. Years of terrible drives her crazy itch of the left arm (she has areas of digging/crusts). After five minutes of itch!

    - Dr Jess M, Dermatologist

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    "I have been trying everything to control the itch and inflammation of my latest dermatomyositis flair. This is the first product that has given me relief."

    - Cyndi T

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    “I have a female patient with Hep C who has already tried Zyrtec, Claritin, Atarax, and Benadryl with disappointing results, as far as controlling the itch and rash. Dermeleve helped her immensely.”

    - Dr Brett F, Dermatologist

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    “Dermeleve is the ONLY product I have used that calms my itching. I’ve used it for eczema and hives, and have had relief within minutes.”

    - Martha H.

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120g Cream


Dermeleve® Cream


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“In the last almost 40 years, this is the first product that has actually calmed my itch.”

- Seth C. M.D.

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30g Cream


Dermeleve® Cream


You Save $5.00 (-20%) + Free Shipping
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“My dermatologist recommended that I get this cream for my back. I’m honestly amazed at how well it works.”

- Ken T.

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How often can I apply Dermeleve® cream?

Dermeleve® is safe to be reapplied as needed throughout the day.

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Who should use Dermeleve®?

Dermeleve® can be used by anyone over the age of two suffering from irritation associated with itching, burning or stinging skin. For children under two check with your doctor to see if Dermeleve® is appropriate.

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Is Dermeleve® safe for sensitive skin?

Yes. Dermeleve® does not thin the skin like steroid products can and is safe for use on sensitive skin.

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What are the ingredients in Dermeleve®?
  • Active ingredient: aluminum acetate 0.2%
  • Inactive Ingredients: Water, Strontium Nitrate, Isopropyl Myristate, Butyrospermum Parkii (shea) Butter, Caprylic/Capric Triglyceride, Cetearyl Alcohol Water, Strontium Nitrate, Isopropyl Myristate, Butyrospermum Parkii (shea) Butter, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Emulsifying Wax NF, Glycerin, Phenoxyethanol, Magnesium Aluminum Silicate, Glyceryl Stearate, Dimethicone, Polyacrylate Crosspolymer-6, Xanthan Gum, Caprylyl Glycol, Sodium Hyaluronate (Hyaluronic Acid), Disodium EDTA, Ceramide NG, Tocopherol (Vitamin E), Tetrahexyldecyl Ascorbate
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Is Dermeleve® steroid-free?

Yes, Dermeleve® is free of hydrocortisone and/or any other steroid. Many itch relief products are steroid-based and may contribute to unwanted side effects such as skin thinning, stretch marks, increased bruising, enlarged blood vessels and more. Dermeleve®’s unique, patented formula was developed to outperform other itch-relief products without the use of steroids.

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Is Dermeleve® tested on animals?

No, our products are never tested on animals.

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What is your return policy?

We stand by all of our products with a 100% satisfaction guarantee. So give Dermeleve® a try! If you are unhappy with your purchase for any reason, we will issue a full refund within thirty (30) days of purchase. No questions asked. Just contact our customer service department at or call 877-684-2299. Once your refund is approved and we receive your remaining product back, we will issue your refund. (Return postage will not be covered).

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What is Aluminum Acetate and is it safe?

Aluminum acetate is a water-soluble salt compound often used in medicine as an astringent or antiseptic. Dermeleve®’s patented formula works with the aluminum acetate to relieve itch and skin irritations. Aluminum Acetate is regulated by the Over-the-Counter (OTC) FDA monograph which describes aluminum-containing topical products used to treat minor skin irritations. These include:

  • Insect bites and stings
  • Itchy rashes from soaps, detergents, cosmetics and jewelry
  • Poison ivy, oak and sumac


Aluminum is found naturally in the human diet in small amounts. According to this article on "Beef, poultry, ham, eggs and fresh fruits have 1 milligram or less of aluminum per kilogram of food, according to a report from the Centers for Disease Control and Prevention. The aluminum in different types of fish ranges between 0.1 and 6 milligrams per kilogram. Most fresh vegetables contain 1 to 4 milligrams per kilogram, except for spinach, which has five times more. Tea leaves are one of the rare plants with a very high aluminum content, but not all of it leaches into the water when you prepare a cup of tea. You may get as much as 3.6 milligrams of aluminum per liter of steeped tea. This is about the same amount as fruit juice, but it’s four times higher than coffee and other beverages.


Aluminum is also used in many antiperspirants at concentrations upwards of 16%, and The National Cancer Institute’s webpage ( states that “no scientific evidence links the use of [antiperspirants] to the development of breast cancer.” Dermeleve® contains 0.2% Aluminum Acetate. This is 80 to 100 times less than standard anti-perspirants on the market.


In a preliminary study of the dermal absorption of aluminum from antiperspirants using aluminum-26 (, “Results indicate that only 0.012% of the applied aluminum was absorbed through the skin. At this rate, about 4 microg of aluminum is absorbed from a single use of ACH on both underarms. This is about 2.5% of the aluminum typically absorbed by the gut from food over the same time period. Therefore, a one-time use of ACH applied to the skin is not a significant contribution to the body burden of aluminum.”


Additional resources on Aluminum: No, you shouldn’t worry about aluminum in your antiperspirant “Antiperspirants and Breast Cancer Risk“ Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

Questions? We’re here to help!


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