If you're struggling with hidradenitis suppurativa (HS), a painful, chronic skin disease, you’re likely frustrated by flare-ups, scarring, and limited treatment options. A new study suggests a surprising ally in the fight against HS: GLP-1 receptor agonists, a class of medications originally developed for type 2 diabetes.
What Is Hidradenitis Suppurativa?
Hidradenitis suppurativa (also called acne inversa) is a long-term inflammatory skin condition marked by painful lumps and boils. These lesions most commonly appear in areas where skin rubs together, such as:
- Armpits
- Groin
- Buttocks
- Under the breasts
Over time, Hidradenitis Suppurativa (HS) can develop into abscesses, draining sinus tracts, and significant scarring.
Common Symptoms
- Recurring painful lumps or nodules
- Foul-smelling drainage from open sores
- Rope-like scar tissue and skin tunneling
- Severe discomfort and emotional distress
How Are HS and Diabetes Connected?
HS is often associated with other inflammatory or metabolic conditions like obesity, PCOS, and type 2 diabetes. Researchers believe insulin resistance and chronic inflammation may be shared mechanisms, making GLP-1 drugs a potential treatment option.
What Are GLP-1 Receptor Agonists?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are injectable medications that:
- Improve insulin sensitivity
- Regulate blood sugar
- Promote weight loss
Popular brands include Ozempic®, Wegovy®, and Mounjaro®.
What the Study Found
A clinical study of 66 patients with HS revealed encouraging results after GLP-1 treatment:
- 54% had reduced symptoms after 6 months
- 67% showed continued improvement at 18 months
- 60% reported reduced pain
Researchers suggest the improvements stem from:
- Weight loss
- Reduced inflammation
- Improved skin healing
Is It Right for You?
GLP-1 drugs are not currently approved for treating HS, but may be considered off-label for people who also have:
- Obesity or insulin resistance
- Type 2 diabetes
- Severe, treatment-resistant HS
Consult your healthcare provider before beginning any new treatment.
Other Treatments for HS
Doctors may recommend a combination of therapies, depending on severity, location, and medical history:
| Treatment Type | Examples |
|---|---|
| Topicals | Antibiotic creams, benzoyl peroxide, retinoids |
| Systemic medications | Hormone therapy, biologics (e.g., adalimumab) |
| Pain relief | NSAIDs, lidocaine patches |
| Surgery | Drainage, excision of sinus tracts |
| Lifestyle | Smoking cessation, weight loss, diet changes |
Daily Relief with Dermeleve
Even between flare-ups, symptom management matters. Dermeleve offers fast, steroid-free skin relief that penetrates deeply to soothe inflammation and support healing—without the risks of long-term steroid use.
Learn more about Dermeleve for HS relief
FAQs
Are GLP-1 drugs safe for people without diabetes?
Yes, but only under medical supervision. Many people take GLP-1s for weight loss and metabolic support.
Do GLP-1 drugs cure HS?
No. HS is a chronic condition, but GLP-1s may help reduce flare-ups and severity.
Is weight loss the only reason GLP-1s help?
No. These drugs may also reduce systemic inflammation and promote better skin healing.
Should I talk to my doctor about this?
Absolutely. A board-certified dermatologist or endocrinologist can help you decide if this therapy makes sense for your health profile.
Note: This article is for informational purposes only and does not constitute medical advice. Please consult your healthcare provider for personalized recommendations.
Dr. Neal Bhatia is a board-certified dermatologist based in San Diego, California. He serves as the Director of Clinical Dermatology at Therapeutics Clinical Research and is the Chief Medical Editor for Practical Dermatology. Additionally, he is an Associate Clinical Professor at Harbor-UCLA Medical Center in Los Angeles, CA. With a background in immunology, Dr. Bhatia has a special interest in mechanisms of therapy, skin cancer, and medical dermatology.
Learn more about Dr. Bhatia and our Medical Advisory Board