The science behind Dermeleve®
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The itch cycle
When itching is triggered either by external stimuli or internal conditions, it triggers an urge to scratch, which in turn results in inflammatory response and skin damage.
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The solution
Dermeleve® was specifically developed by dermatologists to target and reduce the sensation of itch, interrupting this vicious cycle and allowing skin to heal.
Skin healing ingredients
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SrX-38™
Made with strontium mineral salt, clinically proven to suppress sensory irritation and histamine-induced itch.
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Ceramides
Lipid-rich molecules that retain moisture and promote skin regeneration.
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Hyaluronic acid
Hyaluronic acid Increases skin hydration up to 96% and helps heal skin more quickly.
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Vitamins C & E
Antioxidants that help repair and protect skin from damage.
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Shea Butter
Smoothes dry skin while reducing swelling associated with skin conditions.
Hear from Dr. Dasilva

Dermeleve has been a game changer for me in many different itching disorders."

The proof is in the experience
Hear what patients and doctors have to say about Dermeleve®
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“Dermeleve is the ONLY product I have used that calms my itching. I’ve used it for eczema and hives, and have had relief within minutes.”
- Martha H.
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“I had two patients this afternoon, both 60 year old women with airborne contact dermatitis. Both had severe itching for several weeks and both improved 90% within three minutes of the application of Dermeleve anti itch cream. I really love that stuff.”
- Dermatologist
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“I have had this itchy psoriasis on my hands for years! I have tried everything, including steroid ointments, (that I don’t want to use). I tried Dermeleve and immediately the itching was gone.”
- Shannon R.
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“As a pharmacist and psoriasis sufferer, I have searched for years for a product that could alleviate my itch as well as improve the appearance of scaly areas. I have tried numerous over the counter and prescription products and none have provided the results I have been searching for. I decided to try Dermeleve and I found complete relief from the annoying itch after just one day. After several applications the scaly, dry areas began to fade and are were well on their way to healing.”
- Dr Chase V
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“My daughter has been suffering with eczema for years. Products prescribed or over the counter were like putting a bandaid on the problem, until we discovered Dermeleve. My daughter experienced immediate relief & after a few weeks noticed her discoloration/ hyper pigmentation was lightening & her need for scratching had subsided.”
- Laura W.
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“In the last almost 40 years, this is the first product that has actually worked. It has completely relieved my itching and burning and has been the best product I have ever used.”
- Seth C., M.D.
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"I have had chronic hives since I was a baby and other severe skin issues. My dermatologist recommended this cream to me. I’ve used it for almost a week. It works within minutes and lasts upwards of 10 hours. I sleep through the night. No more raw open hives or wounds from scratching the other itchy issues. I am officially giving a 10 ⭐ review and am now a FOREVER Customer. LOVE. LOVE. LOVE.”
- Drina J
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“I must once again sing the praises of DERMELEVE Anti-Itch cream. In both of my itching scabies patients I applied some DERMELEVE in the office and within a minute they were itch-free.”
- Dr Adam C, Dermatologist
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“I have suffered from skin allergies for a very long time. OTC products as well as prescribed cortisone don’t compare with the effect of this product. Run, don’t walk if you need something like this.”
- Erin F.
- Reviews
- Questions

Relief! Love this cream
I use daily for brachial pruritus and it has helped calm the terrible itching on my arms. I’m very happy to have found this amazing product! Also, I’m a beekeeper and it quickly calms honeybee stings and reduces the red welts to almost nothing! I’ve never experienced anything like it. It even out performs CBD cream for those pesky stings
Love giving samples to my patients
Dermeleve has greatly improved the quality of life for some of my itchiest patients. Some are so itchy they can't even wait to try the cream before they leave the office. I have even had one patient order the cream while she was still in the exam room! Recently I had a patient ask if it could come in a pump or with a flip cap instead of the screw top lid, but that is the only other feedback I have gotten about the cream besides that they are so happy to not be as itchy anymore.

Great itch relief instantly
This cream really works wonderful I have Exama on my legs and the ointment I was using takes a while but Dermeleve is instant wonderful product.

Helps so much with itching!
I woke up in the middle of the night with a severe itch, used this product and was able to go back to sleep. I was sold!

Dermeleve Advanced Formula
This cream does exactly what it advertises..it calms itching(this no more scratching)! I have tried everything to get rid of my dry, irritated patches on my arms and legs. This product delivers!
FAQ

Dermeleve® is safe to be reapplied as needed throughout the day.

Dermeleve® has not been tested for use during pregnancy. As with any product that has not been tested, if you are pregnant or breastfeeding, consult your healthcare professional prior to using the product.

If Dermeleve® is applied to extremely dry, open, or abraded skin, you may experience a temporary stinging sensation. This is due to the presence of a salt compound in Dermeleve® and is not harmful. If the stinging is too intense, wash Dermeleve® off the area with mild soap and water.

Yes, Dermeleve® is free of hydrocortisone and/or any other steroid. Many itch relief products are steroid-based and may contribute to unwanted side effects such as skin thinning, stretch marks, increased bruising, enlarged blood vessels and more. Dermeleve®’s unique, patented formula was developed to outperform other itch-relief products without the use of steroids.

Yes, Dermeleve® is gluten free.

Yes, Dermeleve® is free of Peanuts or Tree nuts.

Yes, Dermeleve® is made in the USA

Yes. Dermeleve® cream is an anti-itch cream that is available without a prescription. Dermeleve® is sold through physicians and online via our website.

Yes, Dermeleve® cream is safe to be used as directed for ages two and up. Dermeleve® does not thin the skin like steroid products can. Dermeleve® is safe for use on sensitive skin.

Dermeleve® provides rapid relief for minor skin irritations due to poison ivy, poison oak, poison sumac, insect bites, athlete’s foot and rashes caused by soaps, detergents, cosmetics or jewelry. Dermeleve® soothes dry, itchy skin.

Dermeleve® is a unique formula that has been shown in clinical trials to be effective in a cowage (skin irritant) model of itch.

Dermeleve® has not been tested for use with other topical products. If used in conjunction with another anti-itch agent and irritation occurs, rinse off immediately with water and a mild soap.

Yes, you can use Dermeleve® on dry, itchy skin.

As with any skin care product, care should be used when applying Dermeleve® to broken or abraded skin, as temporary stinging may occur. Dermeleve® is not an anti-infective and should not be used to prevent infection.

Our products are not tested on animals.

Dermeleve® doesn’t contain any animal derived ingredients nor has it been tested on animals, except for humans.

Dermeleve® should not be used on a child that is younger than two years old without consulting his or her physician. Dermeleve® is safe to use on children 2 years old and older.

Dermeleve® doesn’t contain any formaldehyde nor does it contain any parabens for preservation.

Dermeleve® may sting when applied to sensitive skin. We recommend you use caution when applying and ensure that you only use Dermeleve® externally.

Dermeleve® should only be applied externally so we do not recommend using it to soothe your ear canal itch.

Dermeleve® contains an astringent so it may sting the sensitive skin in the delicate eye area. Please use care when applying, but otherwise it is safe to apply on the eyelids or under-eyes.

Dermeleve® is only indicated for external use.

Yes, Dermeleve® can be used on the scalp and should help alleviate symptoms of itching and irritation.

Dermeleve® may be stored in the refrigerator if you desire a thicker consistency.

No it does not.

No it does not.

Dermeleve® cream is considered safe to use on intact scrotal skin. However, please be advised that immediately after the application you may feel a temporary burning sensation. In addition, please follow the precautions and warnings on the label and make sure that no cream comes in contact with mucous membrane tissue. Dermeleve® is for external use only.

Yes. Like all products, Dermeleve® is best if used before the expiration date on the package. Please refer to the package for the expiration date.

The answer is yes, there are many ingredients in cosmetics that are in the alcohol family, scientifically. But they do not have all the same properties or effect. If you read the ingredient label for any commercial beauty product, you would be hard pressed to find one that does not contain some form of alcohol. Anything that ends on -ol, for example -glycol.

Dermeleve® can be used by anyone over the age of two suffering from irritation associated with itching, burning or stinging skin. For children under two check with your doctor to see if Dermeleve® is appropriate.

Active ingredient:
- Aluminum acetate 0.2%
Inactive Ingredients:
- Water
- Strontium Nitrate
- Isopropyl Myristate
- Butyrospermum Parkii (shea) Butter
- Caprylic/Capric Triglyceride
- Cetearyl Alcohol
- Emulsifying Wax NF
- Glycerin
- Phenoxyethanol
- Magnesium Aluminum Silicate
- Glyceryl Stearate
- Dimethicone
- Polyacrylate Crosspolymer-6
- Xanthan Gum
- Caprylyl Glycol
- Sodium Hyaluronate (Hyaluronic Acid)
- Disodium EDTA
- Ceramide NG
- Tocopherol (Vitamin E)
- Tetrahexyldecyl Ascorbate

We stand by all of our products with a 100% satisfaction guarantee. So give Dermeleve® a try! If you are unhappy with your purchase for any reason, we will issue a full refund within thirty (30) days of purchase. No questions asked. Just contact our customer service department at support@dermeleve.com or call 877-684-2299. Once your refund is approved and we receive your remaining product back, we will issue your refund. (Return postage is not be covered).

Aluminum is found naturally in the human diet in small amounts. According to this article on healthfully.com.
Beef, poultry, ham, eggs and fresh fruits have 1 milligram or less of aluminum per kilogram of food, according to a report from the Centers for Disease Control and Prevention. The aluminum in different types of fish ranges between 0.1 and 6 milligrams per kilogram. Most fresh vegetables contain 1 to 4 milligrams per kilogram, except for spinach, which has five times more. Tea leaves are one of the rare plants with a very high aluminum content, but not all of it leaches into the water when you prepare a cup of tea. You may get as much as 3.6 milligrams of aluminum per liter of steeped tea. This is about the same amount as fruit juice, but it’s four times higher than coffee and other beverages.
Aluminum is also used in many antiperspirants at concentrations upwards of 16%, and The National Cancer Institute’s webpage states that “no scientific evidence links the use of [antiperspirants] to the development of breast cancer.”
Dermeleve® contains 0.2% Aluminum Acetate. This is 80 to 100 times less than standard anti-perspirants on the market.
In a preliminary study of the dermal absorption of aluminum from antiperspirants using aluminum-26, “Results indicate that only 0.012% of the applied aluminum was absorbed through the skin. At this rate, about 4 microg of aluminum is absorbed from a single use of ACH on both underarms. This is about 2.5% of the aluminum typically absorbed by the gut from food over the same time period. Therefore, a one-time use of ACH applied to the skin is not a significant contribution to the body burden of aluminum.”
On itchy skin:
Aluminum acetate is a water-soluble salt compound often used in medicine as an astringent or antiseptic. Dermeleve®’s proprietary formula works with the aluminum acetate to relieve itch and skin irritations and protect the skin. Aluminum acetate is regulated under the Over-the-Counter (OTC) FDA monograph which describes aluminum-containing topical products used to treat minor skin irritations. These include:
- Insect bites and stings
- Itchy rashes from soaps, detergents, cosmetics and jewelry
- Poison ivy, oak and sumac
Additional resources on Aluminum:
No, you shouldn’t worry about aluminum in your antiperspirant

Yes.
As of January 01, 2020, the CARES Act provides, for the first time, that flexible spending accounts (FSAs) and health savings accounts (HSAs) include coverage for OTC medications purchased without a prescription and menstrual products.
Dermeleve.com is equipped to accept HSA and FSA cards for all OTC drugs sold through the site, and OTC drugs purchase from a physician’s office or other outlet should also qualify for FSA and HSA purchasing.