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Dermeleve® Cream

Dermeleve® Cream

4.8 / 5 Stars
Dermeleve® is a proprietary topical formulation developed by dermatologists to stop itch at the source. Its SrX-38™ steroid-free formula has been clinically shown to absorb rapidly into the skin and significantly reduce the sensation of itch.

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The science behind Dermeleve®

  • The itch cycle

    When itching is triggered either by external stimuli or internal conditions, it triggers an urge to scratch, which in turn results in inflammatory response and skin damage.

  • The solution

    Dermeleve® was specifically developed by dermatologists to target and reduce the sensation of itch, interrupting this vicious cycle and allowing skin to heal.

Skin healing ingredients

  • Ceramides

    Lipid-rich molecules that retain moisture and promote skin regeneration.

  • Hyaluronic acid

    Hyaluronic acid Increases skin hydration up to 96% and helps heal skin more quickly.

  • Vitamins C & E

    Antioxidants that help repair and protect skin from damage.

  • Shea Butter

    Smoothes dry skin while reducing swelling associated with skin conditions.

  • Aluminum Acetate

    Targets itch at the source, breaking the itch-scratch-inflammation cycle.

Hear from Dr. Dasilva

Dermeleve has been a game changer for me in many different itching disorders."

Dr. Diego Ruiz Dasilva, Board Certified Dermatologist

The proof is in the experience

Hear what patients and doctors have to say about Dermeleve®

  • “Dermeleve is the ONLY product I have used that calms my itching. I’ve used it for eczema and hives, and have had relief within minutes.”

    - Martha H.

  • “I had two patients this afternoon, both 60 year old women with airborne contact dermatitis. Both had severe itching for several weeks and both improved 90% within three minutes of the application of Dermeleve anti itch cream. I really love that stuff.”

    - Dermatologist

  • “I have had this itchy psoriasis on my hands for years! I have tried everything, including steroid ointments, (that I don’t want to use). I tried Dermeleve and immediately the itching was gone.”

    - Shannon R.

  • “As a pharmacist and psoriasis sufferer, I have searched for years for a product that could alleviate my itch as well as improve the appearance of scaly areas. I have tried numerous over the counter and prescription products and none have provided the results I have been searching for. I decided to try Dermeleve and I found complete relief from the annoying itch after just one day. After several applications the scaly, dry areas began to fade and are were well on their way to healing.”

    - Dr Chase V

  • “My daughter has been suffering with eczema for years. Products prescribed or over the counter were like putting a bandaid on the problem, until we discovered Dermeleve. My daughter experienced immediate relief & after a few weeks noticed her discoloration/ hyper pigmentation was lightening & her need for scratching had subsided.”

    - Laura W.

  • “In the last almost 40 years, this is the first product that has actually worked. It has completely relieved my itching and burning and has been the best product I have ever used.”

    - Seth C., M.D.

  • "I have had chronic hives since I was a baby and other severe skin issues. My dermatologist recommended this cream to me. I’ve used it for almost a week. It works within minutes and lasts upwards of 10 hours. I sleep through the night. No more raw open hives or wounds from scratching the other itchy issues. I am officially giving a 10 ⭐ review and am now a FOREVER Customer. LOVE. LOVE. LOVE.”

    - Drina J

  • “I must once again sing the praises of DERMELEVE Anti-Itch cream. In both of my itching scabies patients I applied some DERMELEVE in the office and within a minute they were itch-free.”

    - Dr Adam C, Dermatologist

  • “I have suffered from skin allergies for a very long time. OTC products as well as prescribed cortisone don’t compare with the effect of this product. Run, don’t walk if you need something like this.”

    - Erin F.

Customer Reviews
4.4 Based on 40 Reviews
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Filter Reviews:
Frances W.
United States United States

The jury is still out

The cream seems to calm the itching, but in order to eliminate the itching completely the underlying cause needs to be diagnosed. The cream does give me temporary relief.

Barbara H.
United States United States

Better than Cortisone Cream

I use Dermeleve on my face and scalp. It is soothing, and I don't worry about the skin-thinning effects of cortisone.

Bruce S.
United States United States

Skin cream

Works very good.

Carey A.
United States United States


Effectively reduced itching.

Liz A.
United States United States


Itchy patch is greatly improved and itching no more since using this miracle product. Highly recommend!

40 reviews


How often can I reapply Dermeleve® cream?

Dermeleve® is safe to be reapplied as needed throughout the day.

Can I use Dermeleve® if I am pregnant or breastfeeding?

Dermeleve® has not been tested for use during pregnancy. As with any product that has not been tested, if you are pregnant or breastfeeding, consult your healthcare professional prior to using the product.

Does Dermeleve® sting when applied?

If Dermeleve® is applied to extremely dry, open, or abraded skin, you may experience a temporary stinging sensation. This is due to the presence of a salt compound in Dermeleve® and is not harmful. If the stinging is too intense, wash Dermeleve® off the area with mild soap and water.

Is Dermeleve® steroid-free?

Yes, Dermeleve® is free of hydrocortisone and/or any other steroid. Many itch relief products are steroid-based and may contribute to unwanted side effects such as skin thinning, stretch marks, increased bruising, enlarged blood vessels and more. Dermeleve®’s unique, patented formula was developed to outperform other itch-relief products without the use of steroids.

Is Dermeleve® Gluten free?

Yes, Dermeleve® is gluten free.

Is Dermeleve® free of Peanuts or Tree nuts?

Yes, Dermeleve® is free of Peanuts or Tree nuts.

Is Dermeleve® made in USA?

Yes, Dermeleve® is made in the USA

Is Dermeleve® available over the counter?

Yes. Dermeleve® cream is an anti-itch cream that is available without a prescription. Dermeleve® is sold through physicians and online via our website.

Is Dermeleve® cream safe?

Yes, Dermeleve® cream is safe to be used as directed for ages two and up. Dermeleve® does not thin the skin like steroid products can. Dermeleve® is safe for use on sensitive skin.

For what conditions can Dermeleve® be used?

Dermeleve® provides rapid relief for minor skin irritations due to poison ivy, poison oak, poison sumac, insect bites, athlete’s foot and rashes caused by soaps, detergents, cosmetics or jewelry. Dermeleve® soothes dry, itchy skin.

How does Dermeleve® work?

Dermeleve® is a unique formula that has been shown in clinical trials to be effective in a cowage (skin irritant) model of itch.

Can I use Dermeleve® in conjunction with other topical products?

Dermeleve® has not been tested for use with other topical products. If used in conjunction with another anti-itch agent and irritation occurs, rinse off immediately with water and a mild soap.

Can I use Dermeleve® on dry skin?

Yes, you can use Dermeleve® on dry, itchy skin.

Can I apply Dermeleve® to broken or abraded skin?

As with any skin care product, care should be used when applying Dermeleve® to broken or abraded skin, as temporary stinging may occur. Dermeleve® is not an anti-infective and should not be used to prevent infection.

Are the ingredients or finished product tested on animals?

Our products are not tested on animals.

Can you tell me whether your product contains any ingredients that are derived from animals?

Dermeleve® doesn’t contain any animal derived ingredients nor has it been tested on animals, except for humans.

Can Dermeleve® be used on children under 2 years old?

Dermeleve® should not be used on a child that is younger than two years old without consulting his or her physician. Dermeleve® is safe to use on children 2 years old and older.

Does Dermeleve® contain Formaldehyde?

Dermeleve® doesn’t contain any formaldehyde nor does it contain any parabens for preservation.

Can Dermeleve® be used on skin around the genital area?

Dermeleve® may sting when applied to sensitive skin. We recommend you use caution when applying and ensure that you only use Dermeleve® externally.

Can you put Dermeleve® in an ear canal?

Dermeleve® should only be applied externally so we do not recommend using it to soothe your ear canal itch.

Can Dermeleve® be used on eyelids?

Dermeleve® contains an astringent so it may sting the sensitive skin in the delicate eye area. Please use care when applying, but otherwise it is safe to apply on the eyelids or under-eyes.

Can I use it on hemorrhoids?

Dermeleve® is only indicated for external use.

Can Dermeleve® be used on the scalp?

Yes, Dermeleve® can be used on the scalp and should help alleviate symptoms of itching and irritation.

Can Dermeleve® be stored in the fridge?

Dermeleve® may be stored in the refrigerator if you desire a thicker consistency.

Does Dermeleve® contain Aspirin?

No it does not.

Does Dermeleve® contain an Anti-Inflammatory?

No it does not.

Does Dermeleve® work for Scrotal Pruritus?

Dermeleve® cream is considered safe to use on intact scrotal skin. However, please be advised that immediately after the application you may feel a temporary burning sensation. In addition, please follow the precautions and warnings on the label and make sure that no cream comes in contact with mucous membrane tissue. Dermeleve® is for external use only.

Does Dermeleve® expire?

Yes. Like all products, Dermeleve® is best if used before the expiration date on the package. Please refer to the package for the expiration date.

Does Dermeleve® Contain Alcohol?

The answer is yes, there are many ingredients in cosmetics that are in the alcohol family, scientifically. But they do not have all the same properties or effect. If you read the ingredient label for any commercial beauty product, you would be hard pressed to find one that does not contain some form of alcohol. Anything that ends on -ol, for example -glycol.

Who should use Dermeleve® cream?

Dermeleve® can be used by anyone over the age of two suffering from irritation associated with itching, burning or stinging skin. For children under two check with your doctor to see if Dermeleve® is appropriate.

What are the ingredients in Dermeleve®?

Active ingredient:

  • Aluminum acetate 0.2%

Inactive Ingredients:

  • Water
  • Strontium Nitrate
  • Isopropyl Myristate
  • Butyrospermum Parkii (shea) Butter
  • Caprylic/Capric Triglyceride
  • Cetearyl Alcohol
  • Emulsifying Wax NF
  • Glycerin
  • Phenoxyethanol
  • Magnesium Aluminum Silicate
  • Glyceryl Stearate
  • Dimethicone
  • Polyacrylate Crosspolymer-6
  • Xanthan Gum
  • Caprylyl Glycol
  • Sodium Hyaluronate (Hyaluronic Acid)
  • Disodium EDTA
  • Ceramide NG
  • Tocopherol (Vitamin E)
  • Tetrahexyldecyl Ascorbate
Return Policy & Money Back Guarantee

We stand by all of our products with a 100% satisfaction guarantee. So give Dermeleve® a try! If you are unhappy with your purchase for any reason, we will issue a full refund within thirty (30) days of purchase. No questions asked. Just contact our customer service department at or call 877-684-2299. Once your refund is approved and we receive your remaining product back, we will issue your refund. (Return postage is not be covered).

What is Aluminum Acetate and is it safe?

Aluminum is found naturally in the human diet in small amounts. According to this article on

Beef, poultry, ham, eggs and fresh fruits have 1 milligram or less of aluminum per kilogram of food, according to a report from the Centers for Disease Control and Prevention. The aluminum in different types of fish ranges between 0.1 and 6 milligrams per kilogram. Most fresh vegetables contain 1 to 4 milligrams per kilogram, except for spinach, which has five times more. Tea leaves are one of the rare plants with a very high aluminum content, but not all of it leaches into the water when you prepare a cup of tea. You may get as much as 3.6 milligrams of aluminum per liter of steeped tea. This is about the same amount as fruit juice, but it’s four times higher than coffee and other beverages.

Aluminum is also used in many antiperspirants at concentrations upwards of 16%, and The National Cancer Institute’s webpage states that “no scientific evidence links the use of [antiperspirants] to the development of breast cancer.

Dermeleve® contains 0.2% Aluminum Acetate. This is 80 to 100 times less than standard anti-perspirants on the market.

In a preliminary study of the dermal absorption of aluminum from antiperspirants using aluminum-26, “Results indicate that only 0.012% of the applied aluminum was absorbed through the skin. At this rate, about 4 microg of aluminum is absorbed from a single use of ACH on both underarms. This is about 2.5% of the aluminum typically absorbed by the gut from food over the same time period. Therefore, a one-time use of ACH applied to the skin is not a significant contribution to the body burden of aluminum.

On itchy skin:

Aluminum acetate is a water-soluble salt compound often used in medicine as an astringent or antiseptic. Dermeleve®’s proprietary formula works with the aluminum acetate to relieve itch and skin irritations and protect the skin. Aluminum acetate is regulated under the Over-the-Counter (OTC) FDA monograph which describes aluminum-containing topical products used to treat minor skin irritations. These include:

  • Insect bites and stings
  • Itchy rashes from soaps, detergents, cosmetics and jewelry
  • Poison ivy, oak and sumac

Additional resources on Aluminum:

No, you shouldn’t worry about aluminum in your antiperspirant “Antiperspirants and Breast Cancer Risk

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

Is Dermeleve® covered by HSA and FSA plans?


As of January 01, 2020, the CARES Act provides, for the first time, that flexible spending accounts (FSAs) and health savings accounts (HSAs) include coverage for OTC medications purchased without a prescription and menstrual products. is equipped to accept HSA and FSA cards for all OTC drugs sold through the site, and OTC drugs purchase from a physician’s office or other outlet should also qualify for FSA and HSA purchasing.